DMPT说明书(manual)

化学定义
Chemical definition
二甲基-β-丙酸噻亭英文名：Dimethyl-beta-propiothetin，简称DMPT，其存在方式有两种：一种是二甲基-β-丙酸噻亭盐酸盐(Dimethyl-beta-propiothetin hydrochloride)，CAS：4337-33-1，分子式 C5H11SO2Cl ， 分子量 170.66 ；另一种是二甲基-β-丙酸噻亭氢溴酸盐(Dimethyl-beta-propiothetin hydrobromide)，CAS：20986-22-5，分子式 C5H11SO2Br ， 分子量 216.12 ；其他名称：beta-Dimethylsulfoniopropionate（简称：DMSP）、二甲基丙酸噻啶、二甲基巯基丙酸、二甲基羧乙基锍化物等。

Dimethyl beta propionic acid thetin English Name: Dimethyl-beta-propiothetin, referred to as DMPT, its existence in two ways: A is dimethyl beta - propionic acid thetin hydrochloride (Dimethyl-beta-propiothetin hydrochloride), CAS:4337-33-1, molecular formula C5H11SO2Cl, molecular weight 170.66; another is dimethyl beta - propionic acid thetin hydrobromide Dimethyl-beta-propiothetin preparation, CAS:20986-22-5, molecular formula C5H11SO2Br, molecular weight 2.1612; other names: beta-Dimethylsulfoniopropionate (referred to as: DMSP), dimethylol propionic acid ticlopidine, dimethyl mercaptopropionic acid, dimethyl carboxy ethyl matte of material etc..

性状

Character

白色结晶性粉末，易溶于水，易潮解，易结块（结块不影响效果）。
White crystalline powder, soluble in water, easy to tide solution, easy to agglomerate (not affect the effect of agglomeration).

用途概述

Purpose overview
DMPT是目前发现的效果最好的新一代水产诱食剂，有人用“鱼咬石头”来形象地形容其诱食效果——即使在石头上涂上这种东西，鱼也会去啃咬石头。DMPT最典型的用途是用作钓鱼的饵料，提高饵料的诱食性，使鱼容易咬钩。

DMPT is the best of a new generation of aquatic attractant, people use "the fish to bite the stone image to describe the phagostimulating effect -- even in stone coated with this kind of thing, the fish will be bite the stone. The most typical is the use of DMPT used as fishing bait, improve the palatability of the food, the fish to bite.

DMPT的工业化用途是作为一种绿色水产饲料添加剂，促进水产动物采食，提高其生长速度。

The industrial use of DMPT is as a kind of green feed additive to promote the growth of aquatic animals.

二甲基-β-丙酸噻亭的制备

Preparation of two methyl beta propionate

天然提取法

Natural extraction method

最早的二甲基-β-丙酸噻亭是从海藻中提取的纯天然化合物，事实上发现二甲基-β-丙酸噻亭的过程也是从海藻开始的：科学家观察发现，海水鱼类爱吃海藻，就开始研究海藻中的诱食因子，后来发现导致鱼类爱吃海藻的原因，就是海藻含有天然的DMPT。

The earliest dimethyl beta - propionic acid thetin is pure natural compound extracted from kelp and in fact found dimethyl beta propionic acid thetin also started from seaweed: scientists have observed, seawater fish love to eat seaweed, began to seaweed research attraction factor, and later found the cause of fish to eat algae is seaweed contains natural DMPT.

化学合成法

Chemical synthesis
由于天然提取法生产二甲基-β-丙酸噻亭的成本高、纯度低，不便于工业化，科学家又根据天然DMPT的结构开发了人工合成二甲基-β-丙酸噻亭的方法，使得二甲基-β-丙酸噻亭的大规模应用得以实现。

合成方法一：

二甲基硫醚和3-溴丙酸在溶剂中反应，得到二甲基-β-丙酸噻亭氢溴酸盐，由于3-溴丙酸的价格很高，生产出的产品抗氧化性差，状态不稳定，在无法满足应用，使得这种方法合成的二甲基-β-丙酸噻亭成本太高，无法被消费者接受。

合成方法二：

二甲基硫醚与3-氯丙酸在溶剂反应，得到二甲基-β-丙酸噻亭盐酸盐，由于3-氯丙酸的反应活性比较低，虽然其采购价格低于3-溴丙酸，但反应的收率也低，合成的成本仍然很高。

合成方法三：

北京格林恒兴生物科技有限公司的化学专家吴博士经过多年结合实际生产研究，于2005年开发出新的合成路线，使二甲基-β-丙酸噻亭的生产成本大幅度下降（销售价格只有传统方法的三分之一），并于2007年获得国家发明专利。
Due to the natural extraction production dimethyl beta propionic acid thetine of high cost and low purity, not easy to industrialization, scientists method according to the structure of natural DMPT developed artificial synthesis of dimethyl beta propionic acid thetin, making the large-scale application of dimethyl beta - propionic acid thetin to be realized.

Synthesis method:
Dimethyl sulfide and brominated propionate in the solvent reaction, dimethyl beta - propionic acid thetin hydrobromide, because of the high price of brominated propionate, production of the antioxidant, state of instability, in cannot meet the requirements of application, making this method synthetic dimethyl beta - propionic acid thetin cost is too high, can not be accepted by consumers.

Synthesis method two:

Dimethyl sulfide and 3-chloropropionic acid in the reaction solvent, dimethyl beta - propionic acid thetin hydrochloride, due to the relatively low reactivity of 3-chloropropionate, although the purchase price is lower than the brominated propionate, but the reaction yield low, synthetic cost is still high.

Synthesis method three:

Beijing green evergreen Biological Technology Co., Ltd. chemical expert Dr. Wu after years of combined with practical investigation, in 2005 to develop new synthetic route, make dimethyl beta - propionic acid thetine of a substantial decline in production costs one third of sales price is only the traditional method, and in 2007 won the national invention patent.

DMPT与DMT的异同

Similarities and differences between DMT and DMPT

目前，国内市场上二甲基-β-丙酸噻亭（DMPT）的产品鱼龙混珠，许多不诚实的商家常以类似的产品——硫代甜菜碱（DMT），来冒充二甲基-β-丙酸噻亭（DMPT），有必要区分一下DMPT与DMT的概念，具体不同如下：

At present, the domestic market on Dimethyl beta - propionic acid thetin (DMPT) products ichthyosaurs mixed beads, many dishonest businessmen often with similar product of DMSP (DMT) to impersonate dimethyl beta - propionic acid thetin (DMPT), it is necessary to make a distinction between the concept of DMPT and DMT, the specific difference is as follows:

化学名称不同

Different chemical names

DMPT是二甲基-β-丙酸噻亭，而DMT的化学是二甲基-β-乙酸噻亭；两者根本不是同一个化合物，也不是同一个产品。
DMPT is a two - beta, and DMT's chemistry is the two - methyl - beta - acid, the same compound that is not the same.

生产方法不同

Production method is different
DMPT由二甲基硫醚和3-溴丙酸（或3-氯丙酸）反应得到，而DMT由二甲基硫醚与氯乙酸在催化剂作用下反应合成。

DMPT was prepared by two methyl sulfide and 3- (or 3-), while DMT was synthesized by the reaction of two methyl sulfide and chloride.

生产成本不同

Production costs are different
真正的DMPT的原料生产成本要远远高于DMT的原料生产成本。

Real DMPT raw material production costs to be much higher than the cost of raw material production DMT.

外观、气体不同

Appearance, gas
二甲基-β-丙酸噻亭（DMPT）为纯白色粉末结晶，而硫代甜菜碱（DMT）则为类白色针状结晶体（或粒状结晶体）。

Two methyl - - propionate (DMPT) is a pure white powder crystal, while the betaine (DMT) is a class of white needle like crystal (or granular crystal).

二甲基-β-丙酸噻亭（DMPT）与硫代甜菜碱（DMT）都带有生产原料二甲基硫醚的腥臭味，硫代甜菜碱（DMT）的腥臭味要小于二甲基-β-丙酸噻亭（DMPT）且二者都带有令人不愉快的刺激性味道。

Dimethyl beta propionic acid thetin (DMPT) and DMSP (DMT) with the raw materials for the production of dimethyl sulfide stench, DMSP (DMT) stench to less than dimethyl beta - propionic acid thetin (DMPT) and two with unpleasant pungent taste.

诱食效果不同

The effect of different attractants

DMPT的诱食效果要好于DMT的诱食效果，有实验数据证明。
The phagostimulating effect phagostimulating effect DMPT better than DMT, the experimental data to prove.

自然界存在形式不同

Different forms of nature

真正的DMPT不仅广泛存在海藻体内，也存在于野生的鱼虾体中，在自然界广泛存在；而DMT则在自然界中不存在，是一种纯化学合成的物质。
Real DMPT not only widespread seaweed body, also found in wild fish body, exists widely in nature; and DMT in nature does not exist is a pure synthetic chemical substances.

养殖水产品的风味不同

The flavor of aquatic product is different.

二甲基-β-丙酸噻亭（DMPT）是海水鱼区别于淡水鱼的特征物质，是海产品之所以具有海产品味道（而不是淡水鱼味道）的风味物质之一。 用二甲基-β-丙酸噻亭（DMPT）饲喂的鱼虾，其肉质接近天然野生的鱼虾味道，而DMT则不能达到如此效果。
Two methyl beta - (DMPT) is a feature of marine fish, which is different from freshwater fish. It is one of the flavor substances in the seafood that has a seafood flavor (rather than a fresh fish flavor). Dimethyl beta - propionic acid thetin (DMPT) feeding fish and shrimp, the fleshy close to natural wild fish taste and DMT are not being able to this effect.

DMPT的作用机理

Mechanism of action of DMPT

诱食作用：

Phagostimulating effect:

二甲基-β-丙酸噻亭（DMPT）通过水产动物嗅觉能接受水体中低浓度化学物质的刺激，能区别化学物质且极灵敏，其嗅囔内的褶皱能增加其与外界水环境的接触面积，以提高嗅觉的灵敏度。因此，鱼、虾、蟹类对 DMPT特别有的气味具有很强的诱食生理机制，DMPT正是遵循水产动物这一特有的习性从而来提高水产动物的摄食频次。 　

   作为水产动物诱食促生长剂，对多种海淡水鱼类、虾蟹类的摄食行为和生长具有显著的促进作用。使水产动物咬饵料次数提高，其摄食刺激效果比谷氨酰胺高2.55倍(谷氨酰胺是在DMPT之前对大多数淡海水鱼类已知效果最好的摄食刺激剂)。Mechanism of action of DMPT
Dimethyl beta propionic acid thiazide Pavilion (DMPT) through aquatic animals smell to receiving water of low concentration chemical stimulation, different chemicals and extremely sensitive, sniff the tumult in the fold can increase its contact area with the water environment, to improve the olfactory sensitivity. Therefore, fish, shrimp, crab of DMPT especially some smell has a strong attractant physiological mechanism, DMPT is follow the aquatic animals this peculiar habits to improve aquatic animal feeding frequency.

高效甲基供体，促生长：

High efficient methyl donor, growth promoting:

二甲基-β-丙酸噻亭（DMPT）分子上的 (CH3)2S-基团，具有甲基供体功能，有效地被水产动物利用，促进动物体内消化酶的分泌，促进鱼体的消化和对营养物质的吸收，提高饲料利用率。
Dimethyl beta propionic acid thetin (DMPT) molecules (CH3) 2S groups, with methyl donor function, effectively by aquatic animals use, promote the secretion of digestive enzymes in the animal body, promote fish digestion and nutrient absorption, improve the utilization rate of the feed.

提高抗应激能力、抗渗透压作用：

Improve the anti stress ability, anti osmotic pressure:

提高水产动物的运动能力和抗应激作用（耐高温 耐缺氧），提高幼鱼的适应性和存活率，并可作为体内渗透压缓冲剂，提高水产动物对渗透压激变的耐力。
Improve exercise capacity in aquatic animal and hypoxia tolerance and anti stress effects (high), improve the adaptability of the juvenile and survival rate, and can be used as osmotic pressure buffer, raising aquatic animals of the osmotic pressure of the crisis of the endurance

具有蜕壳素类似作用：

Has the similar role of ecdysone:

二甲基-β-丙酸噻亭（DMPT）具有较强脱壳素样活性，增加虾蟹脱壳速度，尤其是在虾蟹养殖中后期，效果更为明显。蜕壳和促生长机理：甲壳类动物自身能够合成二甲基-β-丙酸噻亭（DMPT），目前的研究表明，对于虾而言，二甲基-β-丙酸噻亭（DMPT）是一个新的水溶性的脱壳激素类似物，通过促进脱壳而促进虾的生长速度。二甲基-β-丙酸噻亭（DMPT）是水产味觉受体的有效配体，对水产动物的味觉、嗅觉神经有极强的刺激作用，从而加快水产动物摄食速度，提高水产动物在应激状态下的采食量。
Dimethyl beta propionic acid thiazide Pavilion (DMPT) has strong hulling element like activity, increasing the speed of shrimp and crab shell, especially in the late period of crabs, the effect is more obvious. Molting and growth mechanism: crustaceans to synthesis of dimethyl beta propionic acid thetin (DMPT), the present study show that for shrimp, dimethyl beta - propionic acid thetin (DMPT) is molting hormone analogues of a new water soluble, through the promotion of shelling and promote the growth rate of shrimp. Dimethyl beta propionic acid thiazide Pavilion (DMPT) is aquatic gustatory receptor ligand, strong stimulating effect on aquatic animals of gustatory, olfactory nerve, so as to speed up the feeding speed of aquatic animals and aquatic animals are improved under the stress of intake.

具有保肝功能

Hepatoprotective function

二甲基-β-丙酸噻亭（DMPT）具有保肝功能，不仅可以提高动物的健康状态，减少内脏/体重比，提高水产动物的可食用性。Dimethyl beta propionic acid thiazide Pavilion (DMPT) with liver protecting function, not only can improve animal health and reduce visceral / body weight ratio and improve the edibility of the aquatic animals.

改善肉质

Improve the meat quality
二甲基-β-丙酸噻亭（DMPT）能改善养殖产品的肉质，使淡水品种呈现海产风味，提高经济价值。Improve the meat quality
Dimethyl beta propionic acid thiazide Pavilion (DMPT) can improve the breed fleshy, freshwater species present seafood flavor, improve economic value.

抗菌作用

Antibacterial action

二甲基-β-丙酸噻亭（DMPT）还具有“大蒜素”类似的保健、抗菌作用。
Two - beta - methyl propionate thetin (DMPT) also has a similar "allicin" health, antibacterial effect.

功效特点

Efficacy characteristics

1、二甲基-β-丙酸噻亭（DMPT）是天然存在的一种含硫化合物，是第四代水产诱食剂之外的新一类诱食剂。二甲基-β-丙酸噻亭（DMPT）的诱食效果是氯化胆碱的1.25倍、甜菜碱的2.56倍、甲基蛋氨酸的1.42倍、谷氨酰胺的1.56倍。谷氨酰胺是氨基酸类诱食剂效果最好的一种，而二甲基-β-丙酸噻亭（DMPT）的效果好于谷氨酰胺；乌贼内脏、蚯蚓的提取物有诱食作用，主要是具有多种氨基酸的原因；扇贝也可作为诱食剂，它的鲜味却是源于二甲基-β-丙酸噻亭（DMPT）；研究表明二甲基-β-丙酸噻亭（DMPT）是目前效果最好的诱食剂。

2、二甲基-β-丙酸噻亭（DMPT）的促生长效果是不添加诱食剂的半天然饵料的2.5倍。

3、二甲基-β-丙酸噻亭（DMPT）还可以改善养殖品种的肉质，使淡水品种呈现海产风味，从而提高淡水品种的经济价值。

4、二甲基-β-丙酸噻亭（DMPT）还是一种脱壳激素类物质，对虾蟹等水产动物的脱壳，加速其脱壳速度有明显效果。

5、二甲基-β-丙酸噻亭（DMPT）为一些相对鱼粉低廉的蛋白质源提供更大利用空间。
1 and 2 methyl beta propionic acid thetin (DMPT) is naturally occurring a sulfur-containing compounds, is the fourth generation of aquatic phagostimulant outside a new class of attractant. The attractant effect of dimethyl beta propionic acid thiazide Pavilion (DMPT) is 1.56 times of 1.42 times of 2.56 times as much as that of the choline chloride 1.25 times, betaine, methyl methionine, glutamine. Glutamine is amino acids phagostimulant effect best, and the effect of dimethyl beta - propionic acid thetin (DMPT) good to glutamine; extracts of squid visceral, earthworms have attractant, mainly with a variety of amino acids; scallops can also be used as attractants, its flavor is source to dimethyl beta - propionic acid thetin (DMPT). The study shows that dimethyl beta - propionic acid thetin (DMPT) is the effect best attractant.

2, two - beta - methyl propionate thetin (DMPT) growth promoting effect is 2.5 times without the addition of semi natural bait attractant.

3, dimethyl beta - propionic acid thetin (DMPT) can also improve the breed fleshy, freshwater species present seafood flavor, so as to improve the freshwater species of economic value.

4, dimethyl beta - propionic acid thetin (DMPT) or a molting hormone substances, the shell of shrimp and other aquatic animals, accelerate the speed of shelling has obvious effect.

5, two - beta - methyl propionate thetin (DMPT) for some relatively low fish meal protein source provides greater use of space.

用法用量及残留问题

Usage dosage and residue problem

【适用对象】：淡水鱼：鲤、鲫、鳗、鳝、虹鳟、罗非鱼等；海水鱼：大黄鱼、真鲷、大菱鲆等；甲壳类：虾、蟹等。

【application】: freshwater fish: carp, crucian carp, eel, eel, trout, tilapia and other; marine fish: large yellow croaker, sea bream, turbot and other crustaceans: shrimp, crab and so on.
【用法用量】：水产饲料推荐用量：虾：300—400克/吨全价料；鱼：100—200克/吨全价料。钓鱼推荐用量0.5—1克，用于春夏秋水温较高和轻度缺氧时效果显著。在低氧水域中表现出色，聚鱼多且持续时间长。本产品可以加入各种形式摄食的饲料，如预混料、浓缩料等，范围也不限于水产饲料，也包括钓饵。将本品直接或间接加入均可，只要诱食剂能和饲料混合均匀即可.

【Dosage of usage】: Shrimp: 300 - 400 g / T full price. Fish: 100 - 200 g / T. The recommended dosage of 0.5 - 1 grams of fish, for the spring and summer autumn high temperature and mild hypoxia effect. In the hypoxic waters, the performance is excellent, and the fish is long and long. This product can be added to various forms of feeding the feed, premixed feed, concentrated feed, such as, range is not limited to aquatic feed, as well as bait. This product can be added directly or indirectly, as long as the attractant can feed and mixed evenly.

【残留问题】：DMPT为水产动物体内天然存在的物质，不存在残留问题，可长期使用。

【residual problem】: DMPT is a natural substance in aquatic animals, there is no residue problem, can be used for a long time.

【包装规格】:25kg。

【package size】: 25kg.

【包装种类】：桶装。

【packing】: Bottled type.
【储藏方法】:密封，贮存于阴凉、通风、干燥处，注意防潮。

【Storage methods】: sealed, stored in a cool, ventilated, dry place, pay attention to moisture.
【保 质 期】:两年。

【period】: two years.
【产品含量】：≥98.5%。

【content】: more than 98.5% products.

【注意事项】DMPT为酸性物质，忌与碱性添加剂直接接触。

【note】 DMPT is acidic material, avoid direct contact with alkaline additives.