硫代甜菜碱（DMT）说明书

Glycine betaine（DMT）manual

硫代甜菜碱

Glycine betaine

硫代甜菜碱的英文名：Sulfobetaine，其中sulfo-代表“硫”元素，翻译为“硫代”，而betaine是甜菜碱的意思。硫代甜菜碱的化学名：二甲基-β-乙酸噻亭（Dimethylthetin，简称DMT，CAS：4727-41-7，分子式：C4H8O2S·HCl，分子量：156.63。其他名称：二甲基硫代乙酸（Dimethylsulfonioacetate，DMSA）
Sulfo-, Sulfobetaine, which represents the "sulfur" element, translated as "betaine", while the ". Chemical name: two C4H8O2S - Dimethylthetin, DMT, CAS:4727-41-7, HCl, molecular weight: 156.63. Other names: two Dimethylsulfonioacetate (DMSA)

硫代甜菜碱的性状

Characteristics of betaine

硫代甜菜碱为白色结晶、有吸湿性，具有特殊气味。

Betaine is a white crystal, with a special smell.

硫代甜菜碱不同于DMPT

Betaine was different from DMPT

目前，水产养殖业许多专业人士都认为，硫代甜菜碱就是DMPT，其实这是错误概念，具体不同如下：

At present, many of the aquaculture industry professionals believe that the betaine is DMPT, in fact, this is the wrong concept, the specific differences are as follows:

化学名称不同:

Different chemical names:

硫代甜菜碱的化学名：二甲基-β-乙酸噻亭（Dimethylthetin，简称DMT），CAS：4727-41-7，分子式：C4H8O2S·HCl，分子量：156.63。而DMPT化学名称：S,S-二甲基-β-丙酸噻亭英文名：Dimethyl-β-propiothetin（简称DMPT），CAS：4337-33-1，分子式：C5H11ClO2S 分子量：170.66。

所以，硫代甜菜碱（DMT）不是大家所说的二甲基-β-丙酸噻亭（DMPT）。

Chemical name: two - Dimethylthetin (DMT), CAS:4727-41-7, molecular formula: HCl - C4H8O2S, molecular weight: 156.63. DMPT chemical name: S, S- two,, Dimethyl-, DMPT, -propiothetin, CAS:4337-33-1, molecular formula: C5H11ClO2S molecular weight: 170.66.

So, the DMPT (DMT) is not what you say.

生产方法不同:

Production method is different:

硫代甜菜碱（DMT）由二甲基硫醚与2-氯乙酸在催化剂作用下反应合成，得到二甲基-β-乙酸噻亭盐酸盐；

二甲基-β-丙酸噻亭（DMPT）则由二甲基硫醚与3-卤丙酸在催化剂作用下反应合成，得到二甲基-β-丙酸噻亭盐酸盐；

DMSP (DMT) by dimethyl sulfide and 2-chloroacetic acid under the action of catalyst synthesis, dimethyl beta - acetic acid thetin hydrochloride;

Dimethyl beta propionic acid thiazide Pavilion (DMPT) is by dimethyl sulfide and - Halo propionic acid under the action of catalyst synthesis, dimethyl beta - propionic acid thetin hydrochloride;

生产成本不同:

Production costs are different:

硫代甜菜碱（DMT）的生产成本要低于二甲基-β-丙酸噻亭（DMPT）生产成本，二者相差至少二倍。

The production cost of the DMPT (DMT) was lower than that of the two.

外观、气体不同:

Appearance, gas:

硫代甜菜碱（DMT）则为类白色针状结晶体（或粒状结晶体），而二甲基-β-丙酸噻亭（DMPT）为纯白色粉末结晶。

硫代甜菜碱（DMT）与二甲基-β-丙酸噻亭（DMPT）都带有生产原料二甲基硫醚的腥臭味，硫代甜菜碱（DMT）的腥臭味要小于二甲基-β-丙酸噻亭（DMPT）且二者都带有令人不愉快的刺激性味道。

（DMT) is a kind of white needle like crystal (or granular crystal), while the two methyl beta propionate (DMPT) is a pure white powder crystal.

DMSP (DMT) and dimethyl beta - propionic acid thetin (DMPT) with raw materials to produce dimethyl sulfide stench, DMSP (DMT) stench to less than dimethyl beta - propionic acid thetin (DMPT) and two with unpleasant pungent taste.

诱食效果不同:

The effect of different attractants:
Two the effect of the methyl - - propionate (DMPT) was better than that of the betaine (DMT).
二甲基-β-丙酸噻亭（DMPT）的效果要好于硫代甜菜碱（DMT）。

自然界存在形式不同：

Different forms of nature:
硫代甜菜碱（DMT）在自然界中不存在，是一种纯化学合成的物质。而二甲基-β-丙酸噻亭（DMPT）不仅广泛存在海藻体内，也存在于野生的鱼虾体中，在自然界广泛存在。

DMT, which is not present in nature, is a kind of pure chemical synthesis. And dimethyl beta - propionic acid thetin (DMPT) widely exists algae in vivo, are also present in wild fish body and in nature.

养殖水产品的风味不同：

The flavor of aquatic product is different:

二甲基-β-丙酸噻亭（DMPT）是海水鱼区别于淡水鱼的特征物质，是海产品之所以具有海产品味道（而不是淡水鱼味道）的风味物质之一。 　

二甲基-β-丙酸噻亭（DMPT）饲喂的鱼虾，其肉质接近天然野生的鱼虾味道，而硫代甜菜碱（DMT）则不能达到如此效果。

Two methyl beta - (DMPT) is a feature of marine fish, which is different from freshwater fish. It is one of the flavor substances in the seafood that has a seafood flavor (rather than a fresh fish flavor).

Dimethyl beta propionic acid thetin (DMPT) feeding the fish, the meat close to natural wild fish taste, and DMSP (DMT) cannot reach such an effect

硫代甜菜碱的用途

The use of betaine

钓鱼应用中目前最理想的饵料诱食类添加剂，也是水产饲料中广泛使用的诱食剂。 医学上用作肿瘤抑制剂。

硫代甜菜碱（DMT）的诱食效果，虽次于二甲基-β-丙酸噻亭（DMPT），但仍强于第一代诱食剂氨酸类物质、第二代诱食剂甜菜碱类、第三代诱食剂氧化三甲胺以及谷氨酰胺，硫代甜菜碱（DMT）被称为第四代诱食剂，二甲基-β-丙酸噻亭（DMPT）则为新一代诱食剂。

Food additives used in fishing bait is currently the most ideal, widely used as attractant in aquatic feed. Medicine used as tumor inhibitor.

The attractant effect of DMSP (DMT), although inferior to dimethyl beta - propionic acid thetin (DMPT), but still strong in the first generation of attractant agent ammonia acid, the second generation of attractant betaine, the third generation of attractant agent oxidation trimethyl amine and glutamine, DMSP (DMT) is known as the fourth generation of attractant, dimethyl beta - propionic acid thetin (DMPT) is a new generation of attractant

硫代甜菜碱的制备

Preparation of glycine betaine

通过北京格林恒兴生物科技有限公司的化学专家吴博士长期结合实际生产研究总结出合成方法。

合成方法一：

二甲基硫醚和2-溴乙酸在溶剂中反应，得到二甲基-β-乙酸噻亭氢溴酸盐。

合成方法二：

二甲基硫醚与2-氯乙酸在溶剂中反应，得到二甲基-β-乙酸噻亭盐酸盐（目前用于实际生产中）。

The Beijing green evergreen Biological Technology Co., Ltd. chemical expert Dr. Wu long-term combined with actual production of synthetic method is summarized.

Two methyl sulfide and 2- bromide in acetic acid solvent reaction, two methyl beta - acetic acid thetin hydrobromide.

Synthesis method two:

Dimethyl sulfide and 2-chloroacetic acid in solvent reaction, dimethyl beta - acetic acid thetin hydrochloride (currently used in the actual production).

硫代甜菜碱的作用机理

Mechanism of action of glycine betaine

硫代甜菜碱（DMT）的作用机理，类似于二甲基-β-丙酸噻亭（DMPT）:

The mechanism of action of the (DMT), similar to that of the two methyl beta propionate (DMPT):

诱食作用

Phagostimulating effect

硫代甜菜碱（DMT）通过水产动物嗅觉能接受水体中低浓度化学物质的刺激，能区别化学物质且极灵敏，其嗅囔内的褶皱能增加其与外界水环境的接触面积，以提高嗅觉的灵敏度。因此，鱼、虾、蟹类对 DMT特别有的气味具有很强的诱食生理机制，DMT正是遵循水产动物这一特有的习性从而来提高水产动物的摄食频次。 作为水产动物诱食促生长剂，对多种海淡水鱼类、虾蟹类的摄食行为和生长具有显著的促进作用。使水产动物咬饵料次数提高，其摄食刺激效果是谷氨酰胺的数倍。

DMSP (DMT) through aquatic animals smell to receiving water of low concentration chemical stimulation, different chemicals and extremely sensitive, sniff the tumult in the fold can increase its contact area with the water environment, to improve the olfactory sensitivity. Therefore, fish, shrimp, crab of DMT especially some smell has a strong attractant physiological mechanism, DMT is follow the aquatic animals this peculiar habits to improve aquatic animal feeding frequency. As attractants for aquatic animals to promote growth agent, for a variety of Sea freshwater fish, shrimps and crabs in the feeding behavior and growth has a significant role in promoting. The aquatic animal bite bait feeding times increased, the stimulating effect of glutamine is several times.

高效甲基供体，促生长

High efficient methyl donor, growth promoting
硫代甜菜碱（DMT）分子上的 (CH3)2S-基团，具有甲基供体功能，有效地被水产动物利用，促进动物体内消化酶的分泌，促进鱼体的消化和对营养物质的吸收，提高饲料利用率。DMSP (DMT) molecules (CH3) 2S groups, with methyl donor function, effectively by aquatic animals use, promote the secretion of digestive enzymes in the animal body, promote fish digestion and nutrient absorption, improve the utilization rate of the feed.

提高抗应激能力、抗渗透压作用

Improve the anti stress ability, anti osmotic pressure
硫代甜菜碱（DMT）能提高水产动物的运动能力和抗应激作用（耐高温 耐缺氧），提高幼鱼的适应性和存活率，并可作为体内渗透压缓冲剂，提高水产动物对渗透压激变的耐力。

DMSP (DMT) can improve exercise capacity in aquatic animal and anti stress effect (high temperature resistant anti hypoxia), improve the adaptability of the juvenile and increase the survival rate, and as in vivo osmotic buffering agent, aquatic animals are improved on the osmotic pressure of the crisis of the endurance.

具有蜕壳素类似作用

Has the similar role of ecdysone

硫代甜菜碱（DMT）具体有脱壳素样活性，增加虾蟹脱壳速度，尤其是在虾蟹养殖中后期，效果更为明显。

DMSP (DMT) specific hulling element like activity, increasing the speed of shrimp and crab shell, especially during the middle and late stages of a crab breeding, the effect is more obvious.

具有保肝功能

Hepatoprotective function
硫代甜菜碱（DMT）具有保肝功能，不仅可以提高动物的健康状态，减少内脏/体重比，提高水产动物的可食用性。

DMSP (DMT) with liver protecting function, not only can improve animal health and reduce visceral / body weight ratio and improve the edibility of the aquatic animals.

硫代甜菜碱的使用方法

The use of the method of the use of the method of

适用对象

Applicable object
淡水鱼：鲤、鲫、鳗、鳝、虹鳟、罗非鱼等；

海水鱼：大黄鱼、真鲷、大菱鲆等；甲壳类：虾、蟹等。

Freshwater fish: carp, crucian carp, eel, eel, trout, tilapia etc.;

Marine fish: large yellow croaker, sea bream, turbot; crustaceans: shrimp, crab etc..

用法用量

Usage dosage

本产品可以加入各种形式摄食的饲料，如预混料、浓缩料等，范围也不限于水产饲料，也包括钓饵。将本品直接或间接加入均可，只要诱食剂能和饲料混合均匀即可。

推荐用量：虾：300—400克/吨全价料；鱼：100—200克/吨全价料。

钓鱼推荐用量0.4~1克/Kg饵料。用于钓鱼饵料时，春夏秋水温较高和轻度缺氧时效果显著。在低氧水域中表现出色，聚鱼多且持续时间长。
This product can be added to various forms of feeding the feed, premixed feed, concentrated feed, such as, range is not limited to aquatic feed, as well as bait. This product can be added directly or indirectly, as long as the attractant can feed and mixed evenly.

Recommended dosage: Shrimp: 300 - 400 g / T total price of fish: 100 - 200 g / T.

Recommended dosage of 0.4~1 g /Kg bait. Used for fishing bait, spring and autumn high temperature and mild hypoxia effect. In the hypoxic waters, the performance is excellent, and the fish is long and long.

【储藏方法】：密封，贮存于阴凉、通风、干燥处，注意防潮。

【Storage methods】: sealed, stored in a cool, ventilated, dry place, pay attention to moisture.

【包装规格】：25kg。

【package size】: 25kg.

【包装种类】：袋装或桶装。

【packing】: bag or drum type.

【保 质 期】:两年。

【period】: two years.
【产品纯度】：≥98.5%。

【Product purity 】: the purity of product is more than 98.5%.